Publications · SusztakLab Biobank

Nat Rev Nephrolreview

Nucleic acid sensing pathways in kidney disease development

Andrade-Silva M, Kang C, Jang Y, Susztak K

PMID 42680946 · doi:10.1038/s41581-026-01120-x

Nephrol Dial Transplant

KDM1A regulates nephron progenitor programs and is associated with human kidney disease risk

Kolligundla LP, Mukhi D, Levinsohn J, Bergerson A, Hou Y, Liu H, Capell BC, Susztak K

PMID 42065705 · doi:10.1093/ndt/gfag073

Nature

Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup

Dumoulin B, Levinsohn J, Klötzer KA, Li C, Mao L, Ha E … Susztak K

PMID 42056516 · doi:10.1038/s41586-026-10363-4 · free full text

Data on this siteHuman Single-Cell Spatial Atlas

Nat Med

Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes

Li C, Richards SM, Quinn G, Abedini A, Zhu M, Verma T … Susztak K

PMID 41986737 · doi:10.1038/s41591-026-04337-2 · free full text

bioRxiv

Multiscale confidence quantification for virtual spatial transcriptomics with UTOPIA

Jin K, Chen Z, Yu X, Yuan M, Schroeder A, Dumoulin B … Li M

PMID 41847009 · doi:10.64898/2026.03.01.708850 · free full text

iScience

Platform-dependent effects of genetic variants on plasma APOL1

Wang QS, Huang J, Chan LJG, Haste N, Olsson N, Gaun A … Baryshnikova A

PMID 41767276 · doi:10.1016/j.isci.2026.114953 · free full text

Cancer Discovcomment

Inflammation-Driven Field Cancerization in End-Stage Kidney Disease

Sager RA, Susztak K, Hakimi AA

PMID 41766431 · doi:10.1158/2159-8290.CD-25-2276

Res Sq

Cross-Modality Alignment of Spatial Transcriptomics, Multiplexed Imaging, and Histology with PHARAOH

Yao S, Jing Z, Jiang S, Li W, Yamamoto Y, Dumoulin B … Li M

PMID 42370255 · doi:10.21203/rs.3.rs-9954002/v1 · free full text

Sci Adv

ELF3 links kidney function GWAS loci to maladaptive epithelial inflammation

Hou Y, Kloetzer K, Dumoulin B, Ha E, Liu H, Mukhi D … Susztak K

PMID 42497247 · doi:10.1126/sciadv.aec6741 · free full text

J Am Soc Nephrol

Single-Cell Resolution Drug Effects of Renin-Angiotensin-Aldosterone Blockade in ZSF1 Rat Diabetic Kidney Disease

Balzer MS, Zhou J, Abedini A, Ma Z, Hou Y, Yadav T … Susztak K

PMID 41563360 · doi:10.1681/ASN.0000000995 · free full text

Data on this siteRAAS Inhibition in DKD Atlas

Kidney Int Rep

Response to the Letter to the Editor Entitled "A Missing Genomic Dimension: The Small but Central Mitochondrial Genome in Diabetic Kidney Disease Genetics"

Sandholm N, Cole JB, Nair V, Brennan E, Giardini E, Haukka JK … GENIE Consortium

PMID 42359274 · doi:10.1016/j.ekir.2026.106572 · free full text

Adv Sci (Weinh)

ACLY-Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation-Associated Fibrosis in Chronic Kidney Disease

Du C, Mukhi D, Li L, Li C, Pan S, Dumoulin B … Susztak K

PMID 41990244 · doi:10.1002/advs.75247 · free full text

Kidney Int Rep

Exome-Wide Analysis Identifies a Rare EXD3 Missense Variant Associated With Diabetic Kidney Disease

Sandholm N, Cole JB, Nair V, Brennan E, Giardini E, Haukka JK … GENIE Consortium

PMID 41541775 · doi:10.1016/j.ekir.2025.09.053 · free full text

Nat Rev Endocrinol

Author Correction: Mechanisms of diabetic kidney disease and established and emerging treatments

Martinez Leon V, Hilburg R, Susztak K

PMID 41073654 · doi:10.1038/s41574-025-01198-6

Nat Rev Endocrinolreview

Mechanisms of diabetic kidney disease and established and emerging treatments

Martinez Leon V, Hilburg R, Susztak K

PMID 40935879 · doi:10.1038/s41574-025-01171-3

bioRxiv

Pixel2Gene enables histology-guided reconstruction and prediction of spatial gene expression

Yao S, Schroeder A, Jiang S, Im S, Park JH, Dumoulin B … Li M

PMID 42124685 · doi:10.64898/2026.02.21.707168 · free full text

bioRxiv

HistoSweep enables cellular-resolution tissue quality control for gigapixel images in digital pathology and spatial omics

Schroeder A, Yu X, Li W, Yuan M, Mao L, Yang J … Li M

PMID 41676712 · doi:10.64898/2026.01.30.702675 · free full text

Circulation

Cell-Specific Inducible Human APOL1 Risk Variant Expression in Mice Causes Hypertension and Renal Damage

Li F, Poudel B, Andrade-Silva M, Wu J, Raman A, Cruz-Morales E … Susztak K

PMID 41376591 · doi:10.1161/CIRCULATIONAHA.124.071351 · free full text

Nat Rev Nephrolreview

Spatial metabolomics and multiomics integration for breakthroughs in precision medicine for kidney disease

Sharma K, Hansen J, Susztak K, Eberlin L, Anderton CR, Alexandrov T, Iyengar R

PMID 41068470 · doi:10.1038/s41581-025-01007-3 · free full text

Kidney Int

Improving the histologic classification of advanced diabetic nephropathy based on the Transformative Research in Diabetic Nephropathy (TRIDENT) findings

Mohandes S, Nast CC, Mottl A, Scialla J, Almaani S, Luciano R … Palmer MB

PMID 42648400 · doi:10.1016/j.kint.2026.07.028

medRxiv

Inherited Susceptibility to Urinary Tract Infections from Kidney Papilla to Bladder

Xu K, Khan A, Shang N, Zeng W, Wang C, Berrouet C … Kiryluk K

PMID 42465954 · doi:10.64898/2026.07.07.26357417 · free full text

Am J Transplant

Marginal zone B cell targeting limits alloantigen availability to follicular dendritic cells and mitigates antibody-mediated rejection

Gassen RB, Liu K, Ganchiku Y, Lima K, Al Jurdi A, Susztak K … Riella LV

PMID 42580442 · doi:10.1016/j.ajt.2026.08.002

Circulation

Response by Poudel and Susztak to Letter Regarding Article, "Cell-Specific Inducible Human APOL1 Risk Variant Expression in Mice Causes Hypertension and Renal Damage"

Poudel B, Susztak K

PMID 42574518 · doi:10.1161/CIRCULATIONAHA.126.081222

Clin J Am Soc Nephrol

Percutaneous Native Kidney Biopsy Complications in Diabetic Patients in the TRIDENT Cohort

Mohandes S, Fakhreddine M, Sheng H, Al Dulaimee M, Mottl A, Scialla J … TRIDENT Consortium

PMID 42295857 · doi:10.2215/CJN.0000001083 · free full text

Nat Genet

Single-cell spatial mapping of human kidney development implicates the microenvironment in guiding cell fate decisions

Levinsohn J, Grindel S, Dumoulin B, Abedini A, Conte C, Huang AZ … Susztak K

PMID 42533102 · doi:10.1038/s41588-026-02665-0 · free full text

Data on this siteHuman Fetal Kidney Spatial Atlas

Science

HNF1B integrates signals in a feed-forward loop driving kidney disease progression

Isnard P, Makinistoglu MP, Leibovici M, Levinsohn J, Zimmermann N, Cohen C … Pontoglio M

PMID 41990178 · doi:10.1126/science.aea3219

ArXiv

Nephrobase Cell+: Multimodal Single-Cell Foundation Model for Decoding Kidney Biology

Li C, Ziyadeh E, Sharma Y, Dumoulin B, Levinsohn J, Ha E … Susztak K

PMID 41256895 · free full text

bioRxiv

Designing smart spatial omics experiments with S2Omics

Yuan M, Jin K, Yan H, Schroeder A, Luo C, Yao S … Li M

PMID 41000647 · doi:10.1101/2025.09.21.677634 · free full text

Sci Rep

Unbiased self supervised learning of kidney histology reveals phenotypic and prognostic insights

Pandit K, Coudray N, Quiros AC, Surapaneni A, Upadhyay D, Vanguri RS … TRIDENT Study Investigators

PMID 41062686 · doi:10.1038/s41598-025-19193-2 · free full text

Cell Stem Cellcomment

From form to function: New heights in kidney organoids

Levinsohn J, Susztak K

PMID 41043401 · doi:10.1016/j.stem.2025.09.003

bioRxiv

Nephrobase Cell+: Multimodal Single-Cell Foundation Model for Decoding Kidney Biology

Li C, Ziyadeh E, Sharma Y, Dumoulin B, Levinsohn J, Ha E … Susztak K

PMID 41256511 · doi:10.1101/2025.09.30.679471 · free full text

J Am Soc Nephrol

Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci

Cole JB, Dahlström EH, Fermin D, Gupta Y, Hill C, Smyth LJ … Hirschhorn JN

PMID 40323663 · doi:10.1681/ASN.0000000718 · free full text

Adv Sci (Weinh)

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre-mRNA

Li C, Marschner JA, Kusunoki Y, Zhang N, Li X, Deng H … Anders HJ

PMID 40834429 · doi:10.1002/advs.202506707 · free full text

Nat Rev Nephrol

Two decades of nephrology research: progress and future challenges

Anandh U, Anders HJ, Bacchetta J, Johnson DW, Luyckx V, Remuzzi G … Yanagita M

PMID 40973937 · doi:10.1038/s41581-025-00996-5

Nat Med

The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health

Hirohama D, Fadista J, Ha E, Liu H, Abedini A, Levinsohn J … Susztak K

PMID 40796935 · doi:10.1038/s41591-025-03872-8 · free full text

Data on this siteHuman Kidney Protein QTL Atlas

Kidney Intreview

APOL1 kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Ojo AO, Adu D, Bramham K, Freedman BI, Gbadegesin RA, Ilori TO … Conference Participants

PMID 40582702 · doi:10.1016/j.kint.2025.05.017 · free full text

Nat Biotechnol

Recovery of biological signals lost in single-cell batch integration with CellANOVA

Zhang Z, Mathew D, Lim TL, Mason K, Martinez CM, Huang S … Zhang NR

PMID 39592777 · doi:10.1038/s41587-024-02463-1

Mol Ther Nucleic Acids

SNA-modified antisense oligonucleotides: A new pathway for renal targeting?

Dumoulin B, Yamada K, Susztak K

PMID 40034209 · doi:10.1016/j.omtn.2025.102476 · free full text

Cell Metab

Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome

Li S, Liu H, Hu H, Ha E, Prasad P, Jenkins BC … Susztak K

PMID 39561766 · doi:10.1016/j.cmet.2024.10.007 · free full text

Science

Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants

Liu H, Abedini A, Ha E, Ma Z, Sheng X, Dumoulin B … Penn Medicine BioBank

PMID 39913582 · doi:10.1126/science.adp4753 · free full text

Data on this siteeGFR GWAS (2.2 million) and ScoreCard

Nat Rev Nephrol

Mitochondrial dysfunction has a central role in diabetic kidney disease

Li S, Susztak K

PMID 39681602 · doi:10.1038/s41581-024-00919-w

Kidney Int

The critical role of endoplasmic reticulum stress and the stimulator of interferon genes (STING) pathway in kidney fibrosis

Andrade-Silva M, Dhillon P, Sanchez-Navarro A, Mukhi D, Hu H, Kolligundla LP … Susztak K

PMID 39566842 · doi:10.1016/j.kint.2024.10.021 · free full text

PLoS Genet

Genetic determinants of zinc homeostasis and its role in cardiometabolic diseases

Sadler MC, Ghobril JP, Borisov O, Perrais M, Schiano G, Petrovic D … Kutalik Z

PMID 41325371 · doi:10.1371/journal.pgen.1011928 · free full text

Nat Cell Biol

Smart spatial omics (S2-omics) optimizes region of interest selection to capture molecular heterogeneity in diverse tissues

Yuan M, Jin K, Yan H, Schroeder A, Luo C, Yao S … Li M

PMID 41298871 · doi:10.1038/s41556-025-01811-w · free full text

Nat Commun

Urinary Complement proteome strongly linked to diabetic kidney disease progression

Md Dom ZI, Moon S, Satake E, Hirohama D, Palmer ND, Lampert H … Niewczas MA

PMID 40775226 · doi:10.1038/s41467-025-62101-5 · free full text

Nat Genet

Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas

Klötzer KA, Abedini A, Li S, Balzer MS, Liang X, Levinsohn J … Susztak K

PMID 40775269 · doi:10.1038/s41588-025-02285-0 · free full text

Data on this siteSISKA Rodent–Human Gene Expression Coordination

bioRxiv

Platform-dependent effects of genetic variants on plasma APOL1

Wang QS, Huang J, Chan L, Haste N, Olsson N, Gaun A … Baryshnikova A

PMID 39975113 · doi:10.1101/2025.01.30.635763 · free full text

Sci Transl Med

Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis

Kolligundla LP, Sullivan KM, Mukhi D, Andrade-Silva M, Liu H, Guan Y … Susztak K

PMID 40267214 · doi:10.1126/scitranslmed.adn3079

Cell Rep

The actin and microtubule network regulator WHAMM is identified as a key kidney disease risk gene

Mukhi D, Kolligundla LP, Doke T, Silva MA, Liu H, Palmer M, Susztak K

PMID 40138314 · doi:10.1016/j.celrep.2025.115462 · free full text

Am J Nephrol

Plasma Transcriptome Profile Associated with Chronic Kidney Disease Progression

Srivastava A, Maienschein-Cline M, Amdur RL, Susztak K, Kopp JB, Cao H … Raj D

PMID 39694024 · doi:10.1159/000542707

Am J Hum Genet

Transcriptome- and proteome-wide association studies identify genes associated with renal cell carcinoma

Dutta D, Guo X, Winter TD, Jahagirdar O, Renal Cancer Genetics Consortium, Ha E … Purdue MP

PMID 39137781 · doi:10.1016/j.ajhg.2024.07.012 · free full text

J Clin Invest

Fibrosis uncovered: ADAMTS12 cuts to the core of extracellular matrix drama

Dumoulin B, Susztak K

PMID 39286974 · doi:10.1172/JCI183115 · free full text

Kidney Int

The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Vivarelli M, Barratt J, Beck LH Jr, Fakhouri F, Gale DP, Goicoechea de Jorge E … for Conference Participants

PMID 38844295 · doi:10.1016/j.kint.2024.05.015

Nat Biotechnol

Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology

Zhang D, Schroeder A, Yan H, Yang H, Hu J, Lee MYY … Li M

PMID 38168986 · doi:10.1038/s41587-023-02019-9 · free full text

J Am Soc Nephrol

METTL3-Mediated N 6 -Methyladenosine mRNA Modification and cGAS-STING Pathway Activity in Kidney Fibrosis

Tsai YC, Hsieh TH, Liao YR, Tsai MT, Lin TP, Lee DY … Li SY

PMID 39352860 · doi:10.1681/ASN.0000000000000428 · free full text

Am J Pathol

Single-Nucleus RNA Sequencing Reveals Loss of Distal Convoluted Tubule 1 Renal Tubules in HIV Viral Protein R Transgenic Mice

Latt KZ, Yoshida T, Shrivastav S, Abedini A, Reece JM, Sun Z … Kopp JB

PMID 39032602 · doi:10.1016/j.ajpath.2024.06.006 · free full text

Nat Commun

TET2 germline variants promote kidney disease by impairing DNA repair and activating cytosolic nucleotide sensors

Liang X, Liu H, Hu H, Ha E, Zhou J, Abedini A … Susztak K

PMID 39511169 · doi:10.1038/s41467-024-53798-x · free full text

Nat Genet

Publisher Correction: A genome-wide association analysis reveals new pathogenic pathways in gout

Major TJ, Takei R, Matsuo H, Leask MP, Sumpter NA, Topless RK … Merriman TR

PMID 39501129 · doi:10.1038/s41588-024-02017-w

Nat Genet

A genome-wide association analysis reveals new pathogenic pathways in gout

Major TJ, Takei R, Matsuo H, Leask MP, Sumpter NA, Topless RK … Merriman TR

PMID 39406924 · doi:10.1038/s41588-024-01921-5

Nephrol Dial Transplant

A comparative scRNAseq data analysis to match mouse models with human kidney disease at the molecular level

Abdank K, Cetin SZ, Abedini A, Susztak K, Eckardt KU, Balzer MS

PMID 38323426 · doi:10.1093/ndt/gfae030 · free full text

bioRxiv

Single-Cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape

Song L, Li Q, Xia L, Sahay A, Qiu Q, Li Y … Wan L

PMID 38766219 · doi:10.1101/2024.05.09.591709 · free full text

Kidney Intreview

The 14th International Podocyte Conference 2023: from podocyte biology to glomerular medicine

Koehler S, Hengel FE, Dumoulin B, Damashek L, Holzman LB, Susztak K, Huber TB, International Podocyte Conference Organizing Committee

PMID 38447880 · doi:10.1016/j.kint.2024.01.042

Int J Mol Sci

Immunological Signatures in Blood and Urine in 80 Individuals Hospitalized during the Initial Phase of COVID-19 Pandemic with Quantified Nicotine Exposure

Laudanski K, Mahmoud MA, Ahmed AS, Susztak K, Mathew A, Chen J

PMID 38612525 · doi:10.3390/ijms25073714 · free full text

Nat Commun

Author Correction: Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development

Yan Y, Liu H, Abedini A, Sheng X, Palmer M, Li H, Susztak K

PMID 38514613 · doi:10.1038/s41467-024-46661-6 · free full text

Cellreview

Diabetes mellitus-Progress and opportunities in the evolving epidemic

Abel ED, Gloyn AL, Evans-Molina C, Joseph JJ, Misra S, Pajvani UB … Drucker DJ

PMID 39059357 · doi:10.1016/j.cell.2024.06.029 · free full text

Nat Commun

Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape

Song L, Li Q, Xia L, Sahay AE, Qiu Q, Li Y … Wan L

PMID 39009564 · doi:10.1038/s41467-024-50171-w · free full text

Kidney Intreview

The key role of altered tubule cell lipid metabolism in kidney disease development

Lee LE, Doke T, Mukhi D, Susztak K

PMID 38614389 · doi:10.1016/j.kint.2024.02.025 · free full text

Nat Commun

Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development

Yan Y, Liu H, Abedini A, Sheng X, Palmer M, Li H, Susztak K

PMID 38287030 · doi:10.1038/s41467-024-45295-y · free full text

J Clin Invest

Single-cell transcriptomics and chromatin accessibility profiling elucidate the kidney-protective mechanism of mineralocorticoid receptor antagonists

Abedini A, Sánchez-Navaro A, Wu J, Klötzer KA, Ma Z, Poudel B … Susztak K

PMID 37906287 · doi:10.1172/JCI157165 · free full text

Data on this siteRat DOCA gene map Rat DOCA snATAC-seq (IGV)

Genome Biol

Niche-DE: niche-differential gene expression analysis in spatial transcriptomics data identifies context-dependent cell-cell interactions

Mason K, Sathe A, Hess PR, Rong J, Wu CY, Furth E … Zhang N

PMID 38217002 · doi:10.1186/s13059-023-03159-6 · free full text

NMR Biomed

MRI-based quantification of whole-organ renal metabolic rate of oxygen

Deshpande RS, Langham MC, Susztak K, Wehrli FW

PMID 37750009 · doi:10.1002/nbm.5036 · free full text

bioRxiv

Genetic Studies Highlight the Role of TET2 and INO80 in DNA Damage Response and Kidney Disease Pathogenesis

Liang X, Liu H, Hu H, Zhou J, Abedini A, Navarro AS, Klötzer KA, Susztak K

PMID 38370682 · doi:10.1101/2024.02.02.578718 · free full text

J Am Soc Nephrol

Is IgA Class Switching Epigenetically Wired?: Untangling the Evidence

Quinn GZ, Susztak K

PMID 39500311 · doi:10.1681/ASN.0000000550 · free full text

Kidney360

A Novel Role for FERM Domain-Containing Protein 3 in CKD

Kennedy C, Doyle R, Gough O, Mcevoy C, McAnallen S, Hughes M … Genie Consortium

PMID 39450948 · doi:10.34067/KID.0000000602 · free full text

Kidney Med

Proteomics and Incident Kidney Failure in Individuals With CKD: The African American Study of Kidney Disease and Hypertension and the Boston Kidney Biopsy Cohort

Chen TK, Surapaneni AL, Schmidt IM, Waikar SS, Coresh J, Liu H … Grams ME

PMID 39634331 · doi:10.1016/j.xkme.2024.100921 · free full text

Am J Kidney Discomment

Genetic Insights into Blood Pressure From Kidney Multi-Omics

Li C, Susztak K

PMID 38986797 · doi:10.1053/j.ajkd.2024.06.006

Kidney Med

Matrix Metalloproteinase-2 and CKD Progression: The Chronic Renal Insufficiency Cohort (CRIC) Study

Baudier RL, Orlandi PF, Yang W, Chen HY, Bansal N, Blackston JW … CRIC Study Investigators

PMID 39131916 · doi:10.1016/j.xkme.2024.100850 · free full text

Nat Genet

Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression

Abedini A, Levinsohn J, Klötzer KA, Dumoulin B, Ma Z, Frederick J … Susztak K

PMID 39048792 · doi:10.1038/s41588-024-01802-x · free full text

Data on this siteHuman Kidney Disease snATAC-seq Human Kidney Spatial Transcriptome Single-Cell Transcriptome (Susztak)Single-Cell Transcriptome (Susztak and KPMP)

Kidney Int

Genome-wide association study of hospitalized patients and acute kidney injury

Siew ED, Hellwege JN, Hung AM, Birkelo BC, Vincz AJ, Parr SK … Velez Edwards DR

PMID 38797326 · doi:10.1016/j.kint.2024.04.019 · free full text

Bioinform Adv

Improve-RRBS: a novel tool to correct the 3' trimming of reduced representation sequencing reads

Fóthi Á, Liu H, Susztak K, Aranyi T

PMID 38846137 · doi:10.1093/bioadv/vbae076 · free full text

bioRxiv

Signal recovery in single cell batch integration

Zhang Z, Mathew D, Lim T, Mason K, Martinez CM, Huang S … Zhang NR

PMID 37215021 · doi:10.1101/2023.05.05.539614 · free full text

Nat Commun

Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization

Onodera T, Wang MY, Rutkowski JM, Deja S, Chen S, Balzer MS … Scherer PE

PMID 37848446 · doi:10.1038/s41467-023-42188-4 · free full text

Kidney Int

Deletion of protein tyrosine phosphatase SHP-1 restores SUMOylation of podocin and reverses the progression of diabetic kidney disease

Lizotte F, Rousseau M, Denhez B, Lévesque D, Guay A, Liu H … Geraldes P

PMID 37507049 · doi:10.1016/j.kint.2023.06.038

bioRxiv

HIV viral protein R induces loss of DCT1-type renal tubules

Latt KZ, Yoshida T, Shrivastav S, Abedini A, Reece JM, Sun Z … Kopp JB

PMID 36945458 · doi:10.1101/2023.02.02.526686 · free full text

J Am Soc Nephrol

Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease

Hung AM, Assimon VA, Chen HC, Yu Z, Vlasschaert C, Triozzi JL … Million Veteran Program

PMID 37798822 · doi:10.1681/ASN.0000000000000219 · free full text

J Am Soc Nephrol

Unified Mouse and Human Kidney Single-Cell Expression Atlas Reveal Commonalities and Differences in Disease States

Zhou J, Abedini A, Balzer MS, Shrestha R, Dhillon P, Liu H, Hu H, Susztak K

PMID 37639336 · doi:10.1681/ASN.0000000000000217 · free full text

Data on this siteMouse Kidney scRNA-seq Atlas

Clin Transl Med

Deep phenotyping of the lipidomic response in COVID-19 and non-COVID-19 sepsis

Meng H, Sengupta A, Ricciotti E, Mrčela A, Mathew D, Mazaleuskaya LL … FitzGerald GA

PMID 37948331 · doi:10.1002/ctm2.1440 · free full text

Nat Commun

DNA methylation markers for kidney function and progression of diabetic kidney disease

Li KY, Tam CHT, Liu H, Day S, Lim CKP, So WY … Ma RCW

PMID 37188670 · doi:10.1038/s41467-023-37837-7 · free full text

Development

Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation

Goodwin AT, John AE, Joseph C, Habgood A, Tatler AL, Susztak K … Jenkins RG

PMID 37102682 · doi:10.1242/dev.201046 · free full text

Nat Medcomment

Unmasking the elusive erythropoietin-producing 'Norn' cell

Abedini A, Klötzer KA, Susztak K

PMID 37130964 · doi:10.1038/s41591-023-02322-7 · free full text

Clin J Am Soc Nephrolcomment

Worsened Outcome in Patients with Membranous Nephropathy Carrying Apolipoprotein L1 High-Risk Genotype

Susztak K

PMID 36764286 · doi:10.2215/CJN.0000000000000098 · free full text

Nat Metab

NAD(+) precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury

Doke T, Mukherjee S, Mukhi D, Dhillon P, Abedini A, Davis JG … Susztak K

PMID 36914909 · doi:10.1038/s42255-023-00761-7 · free full text

Genome Biol

Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage

Schlosser P, Zhang J, Liu H, Surapaneni AL, Rhee EP, Arking DE … Grams ME

PMID 37365616 · doi:10.1186/s13059-023-02993-y · free full text

bioRxiv

Deep Phenotyping of the Lipidomic Response in COVID and non-COVID Sepsis

Meng H, Sengupta A, Ricciotti E, Mrčela A, Mathew D, Mazaleuskaya LL … FitzGerald GA

PMID 37398323 · doi:10.1101/2023.06.02.543298 · free full text

J Am Soc Nephrol

Unbiased Human Kidney Tissue Proteomics Identifies Matrix Metalloproteinase 7 as a Kidney Disease Biomarker

Hirohama D, Abedini A, Moon S, Surapaneni A, Dillon ST, Vassalotti A … Susztak K

PMID 37022120 · doi:10.1681/ASN.0000000000000141 · free full text

Glomerular Disreview

Combing Genome-Wide Association Studies and Single-Cell Analysis to Elucidate the Mechanisms of Kidney Disease: Proceedings of the Henry Shavelle Professorship

Levinsohn J, Li S, Ha E, Susztak K

PMID 38033715 · doi:10.1159/000534678 · free full text

Glomerular Dis

CureGN-Diabetes Study: Rationale, Design, and Methods of a Prospective Observational Study of Glomerular Disease Patients with Diabetes

Mottl AK, Bomback AS, Mariani LH, Coppock G, Jennette JC, Almaani S … Nast CC

PMID 37901700 · doi:10.1159/000531679 · free full text

Nat Commun

Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development

Dhillon P, Mulholland KA, Hu H, Park J, Sheng X, Abedini A … Susztak K

PMID 36732547 · doi:10.1038/s41467-023-36212-w · free full text

J Clin Investreview

Molecular pathways that drive diabetic kidney disease

Mohandes S, Doke T, Hu H, Mukhi D, Dhillon P, Susztak K

PMID 36787250 · doi:10.1172/JCI165654 · free full text

J Clin Invest

ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules

Mukhi D, Li L, Liu H, Doke T, Kolligundla LP, Ha E … Susztak K

PMID 38051585 · doi:10.1172/JCI172963 · free full text

Kidney Int

Erratum to "Deletion of protein tyrosine phosphatase SHP-1 restores SUMOylation of podocin and reverses the progression of diabetic kidney disease." Kidney Int. 2023;104:787-802

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PMID 37981434 · doi:10.1016/j.kint.2023.10.007

Cell Rep Med

Treatment effects of soluble guanylate cyclase modulation on diabetic kidney disease at single-cell resolution

Balzer MS, Pavkovic M, Frederick J, Abedini A, Freyberger A, Vienenkötter J … Susztak K

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Data on this siteRat DKD snRNA-seq (UMAP)

J Am Soc Nephrol

Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment

Liang X, Aranyi T, Zhou J, Guan Y, Hu H, Liu H, Susztak K

PMID 36522157 · doi:10.1681/ASN.2022040460 · free full text

Diabetologia

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease

Sandholm N, Cole JB, Nair V, Sheng X, Liu H, Ahlqvist E … GENIE Consortium

PMID 35763030 · doi:10.1007/s00125-022-05735-0 · free full text

Sci Rep

Multiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the developing mouse kidney

Shao A, Gearhart MD, Chan SC, Miao Z, Susztak K, Igarashi P

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Trends Cell Biolreview

The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development

Doke T, Susztak K

PMID 35473814 · doi:10.1016/j.tcb.2022.03.012 · free full text

Clin J Am Soc Nephrol

APOL1 Kidney Risk Variants and Proteomics

Chen TK, Surapaneni AL, Arking DE, Ballantyne CM, Boerwinkle E, Chen J … Grams ME

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Nat Immunol

Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis

Doke T, Abedini A, Aldridge DL, Yang YW, Park J, Hernandez CM … Susztak K

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Data on this siteMouse UUO scRNA-seq

Mol Ther

Antisense oligonucleotides ameliorate kidney dysfunction in podocyte-specific APOL1 risk variant mice

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PMID 35450819 · doi:10.1016/j.ymthe.2022.04.007 · free full text

Nat Commun

Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration

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Data on this siteMouse Kidney IRI scRNA-seq

Nat Genet

Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease

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Data on this siteeGFRcrea GWAS Kidney eQTL Kidney meQTL Kidney snATAC-seq

Annu Rev Physiolreview

How Many Cell Types Are in the Kidney and What Do They Do?

Balzer MS, Rohacs T, Susztak K

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Kidney Int Rep

Urine Single-Cell RNA Sequencing in Focal Segmental Glomerulosclerosis Reveals Inflammatory Signatures

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Nat Rev Nephrol

From mapping kidney function to mechanism and prediction

Hirohama D, Susztak K

PMID 34819631 · doi:10.1038/s41581-021-00512-5

J Clin Endocrinol Metab

Genetic Variants Associated With Mineral Metabolism Traits in Chronic Kidney Disease

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JAMA Intern Med

APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program

Hung AM, Shah SC, Bick AG, Yu Z, Chen HC, Hunt CM … VA Million Veteran Program COVID-19 Science Initiative

PMID 35089317 · doi:10.1001/jamainternmed.2021.8538 · free full text

Kidney Medreview

Emerging Role of Clinical Genetics in CKD

Devarajan P, Chertow GM, Susztak K, Levin A, Agarwal R, Stenvinkel P, Chapman AB, Warady BA

PMID 35372818 · doi:10.1016/j.xkme.2022.100435 · free full text

Nat Genet

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

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Data on this siteKidney eQTL atlases Kidney snATAC-seq (IGV)

Sci Rep

Longitudinal urinary biomarkers of immunological activation in covid-19 patients without clinically apparent kidney disease versus acute and chronic failure

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PMID 34608231 · doi:10.1038/s41598-021-99102-5 · free full text

J Clin Invest

The key role of NLRP3 and STING in APOL1-associated podocytopathy

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PMID 34651582 · doi:10.1172/JCI136329 · free full text

J Am Soc Nephrol

Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 (HSD17B14) with Reduced Progression to End Stage Kidney Disease in Type 1 Diabetes

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Immunity

APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis

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Sci Adv

Genome-wide association studies identify the role of caspase-9 in kidney disease

Doke T, Huang S, Qiu C, Sheng X, Seasock M, Liu H … Susztak K

PMID 34739325 · doi:10.1126/sciadv.abi8051 · free full text

Sci Rep

Author Correction: Longitudinal urinary biomarkers of immunological activation in covid-19 patients without clinically apparent kidney disease versus acute and chronic failure

Laudanski K, Okeke T, Hajj J, Siddiq K, Rader DJ, Wu J, Susztak K

PMID 34764406 · doi:10.1038/s41598-021-01792-4 · free full text

J Am Soc Nephrol

Renal Histologic Analysis Provides Complementary Information to Kidney Function Measurement for Patients with Early Diabetic or Hypertensive Disease

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J Clin Invest

DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity

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J Clin Invest

Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis

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Clin Epigenetics

Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study

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J Clin Invest

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

Miguel V, Tituaña J, Herrero JI, Herrero L, Serra D, Cuevas P … Lamas S

PMID 33465052 · doi:10.1172/JCI140695 · free full text

J Am Soc Nephrol

Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney

Abedini A, Zhu YO, Chatterjee S, Halasz G, Devalaraja-Narashimha K, Shrestha R … TRIDENT Study Investigators

PMID 33531352 · doi:10.1681/ASN.2020050757 · free full text

J Am Soc Nephrolreview

How to Get Started with Single Cell RNA Sequencing Data Analysis

Balzer MS, Ma Z, Zhou J, Abedini A, Susztak K

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Kidney Int

APOL1 at 10 years: progress and next steps

Freedman BI, Kopp JB, Sampson MG, Susztak K

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Sci Transl Med

Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity

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Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1)

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Cell Metab

The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation

Dhillon P, Park J, Hurtado Del Pozo C, Li L, Doke T, Huang S … Susztak K

PMID 33301705 · doi:10.1016/j.cmet.2020.11.011 · free full text

Data on this siteMouse Folic Acid Nephropathy scRNA-seq

Clin Kidney J

Can kidney parenchyma metabolites serve as prognostic biomarkers for long-term kidney function after nephrectomy for renal cell carcinoma? A preliminary study

Rosenzweig B, Recabal P, Gluck C, Coleman JA, Susztak K, Hakimi AA, Jaimes EA, Weiss RH

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Nat Commun

Meta-analyses identify DNA methylation associated with kidney function and damage

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Nat Commun

Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

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Cell Syst

NAD(+) flux is maintained in aged mice despite lower tissue concentrations

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Kidney Int

Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition

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Trends Genetreview

Gaining insight into metabolic diseases from human genetic discoveries

Claussnitzer M, Susztak K

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Nat Commun

A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis

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Nat Commun

Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

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Data on this siteDeveloping Kidney scRNA-seq Developing Kidney snATAC-seq (IGV)

Kidney Int Rep

The Role of Glomerular Epithelial Injury in Kidney Function Decline in Patients With Diabetic Kidney Disease in the TRIDENT Cohort

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Nat Metab

Defining the lineage of thermogenic perivascular adipose tissue

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Front Immunol

Unbiased Analysis of Temporal Changes in Immune Serum Markers in Acute COVID-19 Infection With Emphasis on Organ Failure, Anti-Viral Treatment, and Demographic Characteristics

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Nat Mach Intell

Iterative transfer learning with neural network for clustering and cell type classification in single-cell RNA-seq analysis

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Proc Natl Acad Sci U S A

Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease

Sheng X, Qiu C, Liu H, Gluck C, Hsu JY, He J … Susztak K

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Data on this siteHuman Blood mQTL Atlas

Kidney Intcomment

The transcriptomic signature of the aging podocyte

Mukhi D, Susztak K

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Nat Rev Nephrolreview

Unravelling the complex genetics of common kidney diseases: from variants to mechanisms

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Nat Commun

Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis

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PLoS Genet

ASEP: Gene-based detection of allele-specific expression across individuals in a population by RNA sequencing

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Kidney Int

Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways

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Semin Nephrolreview

It Takes Two to Tango: The Role of Dysregulated Metabolism and Inflammation in Kidney Disease Development

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J Am Soc Nephrol

Inhibition of Endothelial PHD2 Suppresses Post-Ischemic Kidney Inflammation through Hypoxia-Inducible Factor-1

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Int J Biochem Cell Biol

Loss of ELK1 has differential effects on age-dependent organ fibrosis

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Sci Signalcomment

The interdependence of renal epithelial and endothelial metabolism and cell state

Balzer MS, Susztak K

PMID 32518144 · doi:10.1126/scisignal.abb8834 · free full text

J Immunol

Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses

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Clin J Am Soc Nephrolreview

Complexities of Understanding Function from CKD-Associated DNA Variants

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Clin J Am Soc Nephrol

The Feasibility and Safety of Obtaining Research Kidney Biopsy Cores in Patients with Diabetes: An Interim Analysis of the TRIDENT Study

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Nat Genet

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

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Kidney Intcomment

Rationale and design of the Transformative Research in Diabetic Nephropathy (TRIDENT) Study

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PMID 31901339 · doi:10.1016/j.kint.2019.09.020

Nat Rev Dis Primersreview

Podocytopathies

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Nat Commun

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury

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Elife

Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

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J Am Soc Nephrol

Dnmt3a and Dnmt3b-Decommissioned Fetal Enhancers are Linked to Kidney Disease

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Nat Commun

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

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Sci Rep

Author Correction: FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy

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Cell Metab

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

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Nat Genet

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

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J Am Soc Nephrol

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen

Salem RM, Todd JN, Sandholm N, Cole JB, Chen WM, Andrews D … SUMMIT Consortium, DCCT/EDIC Research Group, GENIE Consortium

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Kidney Intreview

Understanding the kidney one cell at a time

Park J, Liu CL, Kim J, Susztak K

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Sci Rep

Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies

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Going from acute to chronic kidney injury with FoxO3

Gu X, Raman A, Susztak K

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N Engl J Med

Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection

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Nat Med

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes

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Curr Opin Nephrol Hypertensreview

The kidney transcriptome, from single cells to whole organs and back

Huang S, Sheng X, Susztak K

PMID 30844884 · doi:10.1097/MNH.0000000000000495 · free full text

J Clin Invest

Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma

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Long-Range Chromatin Interactions in the Kidney

Guan Y, Liu H, Susztak K

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JCI Insight

Functional methylome analysis of human diabetic kidney disease

Park J, Guan Y, Sheng X, Gluck C, Seasock MJ, Hakimi AA … Susztak K

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Nat Commun

Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease

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Nat Commun

Bulk tissue cell type deconvolution with multi-subject single-cell expression reference

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PLoS Genet

Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting

Symmons O, Chang M, Mellis IA, Kalish JM, Park J, Suszták K, Bartolomei MS, Raj A

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Kidney Int Rep

Associations of Fenofibrate Therapy With Incidence and Progression of CKD in Patients With Type 2 Diabetes

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Nat Genet

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

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Curr Diab Repreview

Cytosine Methylation Studies in Patients with Diabetic Kidney Disease

Aranyi T, Susztak K

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Nat Commun

Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program

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Sci Rep

FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy

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J Am Soc Nephrol

DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development

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PLoS Biol

Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming

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Diabetes

Epigenetics and Epigenomics: Implications for Diabetes and Obesity

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Nat Med

Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease

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Proc Natl Acad Sci U S A

Genomic integration of ERRγ-HNF1β regulates renal bioenergetics and prevents chronic kidney disease

Zhao J, Lupino K, Wilkins BJ, Qiu C, Liu J, Omura Y … Pei L

PMID 29735694 · doi:10.1073/pnas.1804965115 · free full text

Science

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

Park J, Shrestha R, Qiu C, Kondo A, Huang S, Werth M … Suszták K

PMID 29622724 · doi:10.1126/science.aar2131 · free full text

Data on this siteMouse Kidney scRNA-seq Atlas (UMAP)

Semin Nephrolcomment

Introduction: Systems Biology of Kidney Disease

Sharma K, Susztak K, Pennathur S

PMID 29602402 · doi:10.1016/j.semnephrol.2018.02.001 · free full text

Semin Nephrolreview

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) in Kidney Disease

Li SY, Susztak K

PMID 29602395 · doi:10.1016/j.semnephrol.2018.01.003 · free full text

Kidney Int

Cytosine methylation predicts renal function decline in American Indians

Qiu C, Hanson RL, Fufaa G, Kobes S, Gluck C, Huang J … Susztak K

PMID 29709239 · doi:10.1016/j.kint.2018.01.036 · free full text

Cell Chem Biolcomment

Screening Drugs for Kidney Disease: Targeting the Podocyte

Bryer JS, Susztak K

PMID 29452609 · doi:10.1016/j.chembiol.2018.01.018

Trends Mol Medreview

APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease

Beckerman P, Susztak K

PMID 29886044 · doi:10.1016/j.molmed.2018.05.008 · free full text

Endocrinology

In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice

Seki Y, Suzuki M, Guo X, Glenn AS, Vuguin PM, Fiallo A … Charron MJ

PMID 28911167 · doi:10.1210/en.2017-00334 · free full text

Arterioscler Thromb Vasc Biolcomment

APOL1 and Cardiovascular Disease: A Story in Evolution

Bajaj A, Susztak K, Damrauer SM

PMID 28835482 · doi:10.1161/ATVBAHA.117.309756 · free full text

EBioMedicine

Human Kidney Tubule-Specific Gene Expression Based Dissection of Chronic Kidney Disease Traits

Beckerman P, Qiu C, Park J, Ledo N, Ko YA, Park AD … Susztak K

PMID 28970079 · doi:10.1016/j.ebiom.2017.09.014 · free full text

Data on this siteBulk Expression and Disease Correlation

Nat Commun

Epigenome-wide association studies identify DNA methylation associated with kidney function

Chu AY, Tin A, Schlosser P, Ko YA, Qiu C, Yao C … Köttgen A

PMID 29097680 · doi:10.1038/s41467-017-01297-7 · free full text

J Am Soc Nephrol

PGC-1α Protects from Notch-Induced Kidney Fibrosis Development

Han SH, Wu MY, Nam BY, Park JT, Yoo TH, Kang SW … Susztak K

PMID 28751525 · doi:10.1681/ASN.2017020130 · free full text

Curr Diab Repreview

Precision Medicine Approaches to Diabetic Kidney Disease: Tissue as an Issue

Gluck C, Ko YA, Susztak K

PMID 28364354 · doi:10.1007/s11892-017-0854-7 · free full text

Am J Hum Genet

Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease

Ko YA, Yi H, Qiu C, Huang S, Park J, Ledo N … Susztak K

PMID 28575649 · doi:10.1016/j.ajhg.2017.05.004 · free full text

J Lipid Res

Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids

Scerbo D, Son NH, Sirwi A, Zeng L, Sas KM, Cifarelli V … Goldberg IJ

PMID 28404638 · doi:10.1194/jlr.M074427 · free full text

JCI Insight

Increasing the level of peroxisome proliferator-activated receptor γ coactivator-1α in podocytes results in collapsing glomerulopathy

Li SY, Park J, Qiu C, Han SH, Palmer MB, Arany Z, Susztak K

PMID 28724797 · doi:10.1172/jci.insight.92930 · free full text

J Biol Chem

Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer

Bhagat TD, Zou Y, Huang S, Park J, Palmer MB, Hu C … Susztak K

PMID 27909050 · doi:10.1074/jbc.M116.745208 · free full text

J Biol Chem

Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1

Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL … Gupta V

PMID 27913625 · doi:10.1074/jbc.M116.753822 · free full text

Nephrol Dial Transplantreview

Therapeutics for APOL1 nephropathies: putting out the fire in the podocyte

Heymann J, Winkler CA, Hoek M, Susztak K, Kopp JB

PMID 28391347 · doi:10.1093/ndt/gfw402 · free full text

Nat Med

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

Beckerman P, Bi-Karchin J, Park AS, Qiu C, Dummer PD, Soomro I … Susztak K

PMID 28218918 · doi:10.1038/nm.4287 · free full text

Kidney Blood Press Res

A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice

Kruse M, Fiallo A, Tao J, Susztak K, Amann K, Katz EB, Charron MJ

PMID 28750406 · doi:10.1159/000479383

PLoS One

Benign and tumor parenchyma metabolomic profiles affect compensatory renal growth in renal cell carcinoma surgical patients

Rosenzweig B, Rubinstein ND, Reznik E, Shingarev R, Juluru K, Akin O … Hakimi AA

PMID 28727768 · doi:10.1371/journal.pone.0180350 · free full text

PLoS One

Genome-Wide Association of Copy Number Polymorphisms and Kidney Function

Li M, Carey J, Cristiano S, Susztak K, Coresh J, Boerwinkle E … Scharpf RB

PMID 28135296 · doi:10.1371/journal.pone.0170815 · free full text

J Clin Investcomment

The long noncoding RNA Tug1 connects metabolic changes with kidney disease in podocytes

Li SY, Susztak K

PMID 27760046 · doi:10.1172/JCI90828 · free full text

Semin Nephrolreview

Developing Treatments for Chronic Kidney Disease in the 21st Century

Breyer MD, Susztak K

PMID 27987541 · doi:10.1016/j.semnephrol.2016.08.001 · free full text

Curr Diab Repreview

Podocytes: the Weakest Link in Diabetic Kidney Disease?

Lin JS, Susztak K

PMID 27053072 · doi:10.1007/s11892-016-0735-5 · free full text

EBioMedicinecomment

Fat Burning Problem in Cystic Kidneys: an Emerging Common Mechanism of Chronic Kidney Disease

Li SY, Susztak K

PMID 27077105 · doi:10.1016/j.ebiom.2016.02.035 · free full text

Diabetes

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes

Teumer A, Tin A, Sorice R, Gorski M, Yeo NC, Chu AY … Köttgen A

PMID 26631737 · doi:10.2337/db15-1313 · free full text

Nat Rev Nephrolreview

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog

Edeling M, Ragi G, Huang S, Pavenstädt H, Susztak K

PMID 27140856 · doi:10.1038/nrneph.2016.54 · free full text

Nat Commun

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V … Fox CS

PMID 26831199 · doi:10.1038/ncomms10023 · free full text

Trends Mol Medcomment

Epithelial Plasticity versus EMT in Kidney Fibrosis

Huang S, Susztak K

PMID 26700490 · doi:10.1016/j.molmed.2015.11.009 · free full text

Cell Rep

Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice

Kang HM, Huang S, Reidy K, Han SH, Chinga F, Susztak K

PMID 26776520 · doi:10.1016/j.celrep.2015.12.071 · free full text

Cancer

Validation and genomic interrogation of the MET variant rs11762213 as a predictor of adverse outcomes in clear cell renal cell carcinoma

Hakimi AA, Ostrovnaya I, Jacobsen A, Susztak K, Coleman JA, Russo P … Klein RJ

PMID 26505625 · doi:10.1002/cncr.29765 · free full text

Arterioscler Thromb Vasc Biolcomment

APOL1 Variants: From Parasites to Kidney Function to Cardiovascular Disease

Reiner AP, Susztak K

PMID 26819463 · doi:10.1161/ATVBAHA.115.306794 · free full text

J Am Soc Nephrol

Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism

Han SH, Malaga-Dieguez L, Chinga F, Kang HM, Tao J, Reidy K, Susztak K

PMID 26054542 · doi:10.1681/ASN.2014121181 · free full text

J Am Soc Nephrol

Partitioning-Defective 1a/b Depletion Impairs Glomerular and Proximal Tubule Development

Akchurin O, Du Z, Ramkellawan N, Dalal V, Han SH, Pullman J … Reidy KJ

PMID 27185860 · doi:10.1681/ASN.2014111124 · free full text

Nat Rev Drug Discovreview

The next generation of therapeutics for chronic kidney disease

Breyer MD, Susztak K

PMID 27230798 · doi:10.1038/nrd.2016.67 · free full text

Diabetologia

SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes

Germain M, Pezzolesi MG, Sandholm N, McKnight AJ, Susztak K, Lajer M … Hadjadj S

PMID 25476525 · doi:10.1007/s00125-014-3459-6 · free full text

J Am Soc Nephrol

Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD

Ledo N, Ko YA, Park AS, Kang HM, Han SY, Choi P, Susztak K

PMID 25231882 · doi:10.1681/ASN.2014010028 · free full text

Nat Rev Dis Primersreview

Diabetic kidney disease

Thomas MC, Brownlee M, Susztak K, Sharma K, Jandeleit-Dahm KA, Zoungas S … Cooper ME

PMID 27188921 · doi:10.1038/nrdp.2015.18 · free full text

Cell Rep

Diet-Induced Podocyte Dysfunction in Drosophila and Mammals

Na J, Sweetwyne MT, Park AS, Susztak K, Cagan RL

PMID 26190114 · doi:10.1016/j.celrep.2015.06.056 · free full text

J Hematol Oncolreview

Role of DNA methylation in renal cell carcinoma

Shenoy N, Vallumsetla N, Zou Y, Galeas JN, Shrivastava M, Hu C, Susztak K, Verma A

PMID 26198328 · doi:10.1186/s13045-015-0180-y · free full text

Curr Diab Repreview

The evolving understanding of the contribution of lipid metabolism to diabetic kidney disease

Stadler K, Goldberg IJ, Susztak K

PMID 25957525 · doi:10.1007/s11892-015-0611-8 · free full text

Nat Med

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

Kang HM, Ahn SH, Choi P, Ko YA, Han SH, Chinga F … Susztak K

PMID 25419705 · doi:10.1038/nm.3762 · free full text

Am J Physiol Renal Physiol

The long noncoding RNA landscape in hypoxic and inflammatory renal epithelial injury

Lin J, Zhang X, Xue C, Zhang H, Shashaty MG, Gosai SJ … Reilly MP

PMID 26400545 · doi:10.1152/ajprenal.00290.2015 · free full text

Diabetes

Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy Development

Sweetwyne MT, Gruenwald A, Niranjan T, Nishinakamura R, Strobl LJ, Susztak K

PMID 26293507 · doi:10.2337/db15-0260 · free full text

Nephrol Dial Transplantreview

Epigenetics: a new way to look at kidney diseases

Beckerman P, Ko YA, Susztak K

PMID 24675284 · doi:10.1093/ndt/gfu026 · free full text

Kidney Int Suppl (2011)review

Kick it up a notch: Notch signaling and kidney fibrosis

Sweetwyne MT, Tao J, Susztak K

PMID 26312157 · doi:10.1038/kisup.2014.17 · free full text

J Am Soc Nephrolcomment

Sweet debate: fructose versus glucose in diabetic kidney disease

Beckerman P, Susztak K

PMID 24876119 · doi:10.1681/ASN.2014050433 · free full text

J Clin Investreview

Molecular mechanisms of diabetic kidney disease

Reidy K, Kang HM, Hostetter T, Susztak K

PMID 24892707 · doi:10.1172/JCI72271 · free full text

BMC Genet

Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations

Scharpf RB, Mireles L, Yang Q, Köttgen A, Ruczinski I, Susztak K … Linda Kao WH

PMID 25007794 · doi:10.1186/1471-2156-15-81 · free full text

J Am Soc Nephrolreview

Understanding the epigenetic syntax for the genetic alphabet in the kidney

Susztak K

PMID 24179169 · doi:10.1681/ASN.2013050461 · free full text

Am J Physiol Cell Physiolcomment

The hyperglycemic and hyperinsulinemic combo gives you diabetic kidney disease immediately. Focus on "Combined acute hyperglycemic and hyperinsulinemic clamp induced profibrotic and proinflammatory responses in the kidney"

Han SH, Susztak K

PMID 24336650 · doi:10.1152/ajpcell.00371.2013 · free full text

Dis Model Mech

'Back and forth' from models to patients to understand kidney disease: an interview with Katalin Susztak

Susztak K, Cifra A

PMID 25481011 · doi:10.1242/dmm.018911 · free full text

Clin Cancer Res

Kidney cancer is characterized by aberrant methylation of tissue-specific enhancers that are prognostic for overall survival

Hu CY, Mohtat D, Yu Y, Ko YA, Shenoy N, Bhattacharya S … Verma A

PMID 24916699 · doi:10.1158/1078-0432.CCR-14-0494 · free full text

Nephrol Dial Transplant

DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study

Wing MR, Devaney JM, Joffe MM, Xie D, Feldman HI, Dominic EA … Chronic Renal Insufficiency Cohort (CRIC) Study

PMID 24516231 · doi:10.1093/ndt/gft537 · free full text

J Am Soc Nephrolcomment

Notch ties a knot on fistula maturation

Dember LM, Susztak K

PMID 24480826 · doi:10.1681/ASN.2014010005 · free full text

Kidney Int

A multicolor podocyte reporter highlights heterogeneous podocyte changes in focal segmental glomerulosclerosis

Tao J, Polumbo C, Reidy K, Sweetwyne M, Susztak K

PMID 24284512 · doi:10.1038/ki.2013.463 · free full text

Clin J Am Soc Nephrol

Diabetic nephropathy: a national dialogue

Breyer MD, Coffman TM, Flessner MF, Fried LF, Harris RC, Ketchum CJ … Kidney Research National Dialogue (KRND)

PMID 23788618 · doi:10.2215/CJN.03640413 · free full text

Nat Medcomment

Sirt1-Claudin-1 crosstalk regulates renal function

Nihalani D, Susztak K

PMID 24202384 · doi:10.1038/nm.3386

Kidney Intcomment

For better or worse: a niche for Notch in parietal epithelial cell activation

Sweetwyne MT, Susztak K

PMID 23728000 · doi:10.1038/ki.2013.66 · free full text

Semin Nephrolreview

Epigenomics: the science of no-longer-junk DNA. Why study it in chronic kidney disease?

Ko YA, Susztak K

PMID 24011577 · doi:10.1016/j.semnephrol.2013.05.007 · free full text

J Am Soc Nephrol

Adiponectin promotes functional recovery after podocyte ablation

Rutkowski JM, Wang ZV, Park AS, Zhang J, Zhang D, Hu MC … Scherer PE

PMID 23334396 · doi:10.1681/ASN.2012040414 · free full text

Nat Med

Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags

Hackl MJ, Burford JL, Villanueva K, Lam L, Suszták K, Schermer B, Benzing T, Peti-Peterdi J

PMID 24270544 · doi:10.1038/nm.3405 · free full text

J Clin Investcomment

ADCK4 "reenergizes" nephrotic syndrome

Malaga-Dieguez L, Susztak K

PMID 24270414 · doi:10.1172/JCI73168 · free full text

Genome Biol

Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development

Ko YA, Mohtat D, Suzuki M, Park AS, Izquierdo MC, Han SY … Susztak K

PMID 24098934 · doi:10.1186/gb-2013-14-10-r108 · free full text

PLoS One

Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development

Wang Y, Wu B, Chamberlain AA, Lui W, Koirala P, Susztak K … Zhou B

PMID 23560082 · doi:10.1371/journal.pone.0060244 · free full text

Exp Cell Resreview

Notch signaling in diabetic nephropathy

Bonegio R, Susztak K

PMID 22414874 · doi:10.1016/j.yexcr.2012.02.036 · free full text

Autophagyreview

Emerging role of autophagy in kidney function, diseases and aging

Huber TB, Edelstein CL, Hartleben B, Inoki K, Jiang M, Koya D … Dong Z

PMID 22692002 · doi:10.4161/auto.19821 · free full text

Semin Nephrolreview

Repair problems in podocytes: Wnt, Notch, and glomerulosclerosis

Kato H, Susztak K

PMID 22958489 · doi:10.1016/j.semnephrol.2012.06.006 · free full text

J Patholreview

Notch in the kidney: development and disease

Sirin Y, Susztak K

PMID 21952830 · doi:10.1002/path.2967 · free full text

Diabetes

Transcriptome analysis of human diabetic kidney disease

Woroniecka KI, Park AS, Mohtat D, Thomas DB, Pullman JM, Susztak K

PMID 21752957 · doi:10.2337/db10-1181 · free full text

Pediatr Nephrolreview

Fetal environment, epigenetics, and pediatric renal disease

Woroniecki R, Gaikwad AB, Susztak K

PMID 21174217 · doi:10.1007/s00467-010-1714-8 · free full text

J Biol Chem

Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival

Kato H, Gruenwald A, Suh JH, Miner JH, Barisoni-Thomas L, Taketo MM … Susztak K

PMID 21613219 · doi:10.1074/jbc.M111.223164 · free full text

Curr Opin Nephrol Hypertensreview

The story of Notch and chronic kidney disease

Sharma S, Sirin Y, Susztak K

PMID 21088575 · doi:10.1097/MNH.0b013e3283414c88 · free full text

Kidney Intcomment

Tracing the footsteps of glomerular insulin signaling in diabetic kidney disease

Chang GY, Park AS, Susztak K

PMID 21451535 · doi:10.1038/ki.2010.559 · free full text

Semin Nephrolreview

Fine tuning gene expression: the epigenome

Mohtat D, Susztak K

PMID 21044758 · doi:10.1016/j.semnephrol.2010.07.004 · free full text

Kidney Int

Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function

Murea M, Park JK, Sharma S, Kato H, Gruenwald A, Niranjan T … Susztak K

PMID 20531454 · doi:10.1038/ki.2010.172 · free full text

Kidney Int

A susceptibility gene for kidney disease in an obese mouse model of type II diabetes maps to chromosome 8

Chua S Jr, Li Y, Liu SM, Liu R, Chan KT, Martino J … Gharavi AG

PMID 20520596 · doi:10.1038/ki.2010.160 · free full text

J Clin Invest

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S … Susztak K

PMID 20978353 · doi:10.1172/JCI43025 · free full text

Diabetes

Getting a notch closer to understanding diabetic kidney disease

Ahn SH, Susztak K

PMID 20668292 · doi:10.2337/db10-0077 · free full text

Am J Kidney Discomment

Epithelial-mesenchymal transition and podocyte loss in diabetic kidney disease

Reidy K, Susztak K

PMID 19781451 · doi:10.1053/j.ajkd.2009.07.003 · free full text

J Am Soc Nephrolreview

Mouse models of diabetic nephropathy

Brosius FC 3rd, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB … Animal Models of Diabetic Complications Consortium

PMID 19729434 · doi:10.1681/ASN.2009070721 · free full text

Nephron Exp Nephrolreview

The pathogenic role of Notch activation in podocytes

Niranjan T, Murea M, Susztak K

PMID 19293596 · doi:10.1159/000209207 · free full text

PLoS One

Human and murine kidneys show gender- and species-specific gene expression differences in response to injury

Si H, Banga RS, Kapitsinou P, Ramaiah M, Lawrence J, Kambhampati G … Susztak K

PMID 19277126 · doi:10.1371/journal.pone.0004802 · free full text

J Am Soc Nephrol

The role of osteopontin in the development of albuminuria

Lorenzen J, Shah R, Biser A, Staicu SA, Niranjan T, Garcia AM … Susztak K

PMID 18443355 · doi:10.1681/ASN.2007040486 · free full text

Nat Med

The Notch pathway in podocytes plays a role in the development of glomerular disease

Niranjan T, Bielesz B, Gruenwald A, Ponda MP, Kopp JB, Thomas DB, Susztak K

PMID 18311147 · doi:10.1038/nm1731

Kidney Intcomment

Animal models of renal disease

Susztak K, Bitzer M, Meyer TW, Hostetter TH

PMID 18274542 · doi:10.1038/sj.ki.5002724

Diabetescomment

Smad1 as a biomarker for diabetic nephropathy

Kato H, Si H, Hostetter T, Susztak K

PMID 18511448 · doi:10.2337/db08-0365

Diabetes

Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice

Szabó C, Biser A, Benko R, Böttinger E, Suszták K

PMID 17065336 · doi:10.2337/db06-0147

Diabetes

Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy

Susztak K, Raff AC, Schiffer M, Böttinger EP

PMID 16380497

J Am Soc Nephrolreview

Diabetic nephropathy: a frontier for personalized medicine

Susztak K, Böttinger EP

PMID 16407421 · doi:10.1681/ASN.2005101109

Am J Physiol Renal Physiol

Localization of the GLUT8 glucose transporter in murine kidney and regulation in vivo in nondiabetic and diabetic conditions

Schiffer M, Susztak K, Ranalletta M, Raff AC, Böttinger EP, Charron MJ

PMID 15741607 · doi:10.1152/ajprenal.00234.2004

PLoS Med

Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy

Susztak K, Ciccone E, McCue P, Sharma K, Böttinger EP

PMID 15737001 · doi:10.1371/journal.pmed.0020045 · free full text

Diabetes

Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease

Susztak K, Böttinger E, Novetsky A, Liang D, Zhu Y, Ciccone E … Sharma K

PMID 14988265 · doi:10.2337/diabetes.53.3.784

J Am Soc Nephrolreview

Genomic strategies for diabetic nephropathy

Susztak K, Sharma K, Schiffer M, McCue P, Ciccone E, Böttinger EP

PMID 12874445 · doi:10.1097/01.asn.0000078035.81397.8a

Kidney Int Supplreview

Smad proteins and transforming growth factor-beta signaling

Schiffer M, von Gersdorff G, Bitzer M, Susztak K, Böttinger EP

PMID 10997690 · doi:10.1046/j.1523-1755.2000.07708.x

J Biol Chem

Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta

von Gersdorff G, Susztak K, Rezvani F, Bitzer M, Liang D, Böttinger EP

PMID 10753944 · doi:10.1074/jbc.275.15.11320

Biochem J

Electrogenic H+ pathway contributes to stimulus-induced changes of internal pH and membrane potential in intact neutrophils: role of cytoplasmic phospholipase A2

Suszták K, Mócsai A, Ligeti E, Kapus A

PMID 9230134 · doi:10.1042/bj3250501 · free full text

FEBS Lett

Arachidonic acid activatable electrogenic H+ transport in the absence of cytochrome b558 in human T lymphocytes

Káldi K, Szászi K, Koncz G, Suszták K, Ligeti E

PMID 8641428 · doi:10.1016/0014-5793(96)00105-6

FEBS Lett

Ligands of purinergic receptors stimulate electrogenic H(+)-transport of neutrophils

Suszták K, Káldi K, Kapus A, Ligeti E

PMID 7498486 · doi:10.1016/0014-5793(95)01181-d

Biochem J

Lymphocytes possess an electrogenic H(+)-transporting pathway in their plasma membrane

Káldi K, Szászi K, Suszták K, Kapus A, Ligeti E

PMID 7519007 · doi:10.1042/bj3010329 · free full text

Biochem J

Regulation of the electrogenic H+ channel in the plasma membrane of neutrophils: possible role of phospholipase A2, internal and external protons

Kapus A, Suszták K, Ligeti E

PMID 7684901 · doi:10.1042/bj2920445 · free full text

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