Susztaklab Kidney Biobank

Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration.

Michael S. Balzer, Tomohito Doke, Ya-Wen Yang, Daniel L. Aldridge, Hailong Hu, Hung Mai, Dhanunjay Mukhi, Ziyuan Ma, Rojesh Shrestha, Matthew B. Palmer, Christopher A. Hunter and Katalin Susztak

Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.

Hongbo Liu, Tomohito Doke, Dong Guo, Xin Sheng, Ziyuan Ma, Joseph Park, Ha My T. Vy, Girish N. Nadkarni, Amin Abedini, Zhen Miao, Matthew Palmer, Benjamin F. Voight, Hongzhe Li, Christopher D. Brown, Marylyn D. Ritchie, Yan Shu and Katalin Susztak

Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis.

Tomohito Doke, Amin Abedini, Daniel L. Aldridge, Ya-Wen Yang, Jihwan Park, Christina M. Hernandez, Michael S. Balzer, Rojesh Shrestra, Gaia Coppock, Juan M. Inclan Rico, Seung Yub Han, Junhyong Kim, Sheng Xin, Adrian M. Piliponsky, Marco Angelozzi, Veronique Lefebvre, Mark C. Siracusa, Christopher A. Hunter and Katalin Susztak

Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets.

Zhen Miao, Michael S. Balzer, Ziyuan Ma, Hongbo Liu, Junnan Wu, Rojesh Shrestha, Tamas Aranyi, Amy Kwan, Ayano Kondo, Marco Pontoglio, Junhyong Kim, Mingyao Li, Klaus H. Kaestner and Katalin Susztak

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments.

Xin Sheng, Yuting Guan, Ziyuan Ma, Junnan Wu, Hongbo Liu, Chengxiang Qiu, Steven Vitale, Zhen Miao, Matthew J. Seasock, Matthew Palmer, Myung K. Shin, Kevin L. Duffin, Steven S. Pullen, Todd L. Edwards, Jacklyn N. Hellwege, Adriana M. Hung, Mingyao Li, Benjamin F. Voight, Thomas M. Coffman, Christopher D. Brown and Katalin Susztak

The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.

Poonam Dhillon, Jihwan Park, Carmen Hurtado Del Pozo, Lingzhi Li, Tomohito Doke, Shizheng Huang, Juanjuan Zhao, Hyun Mi Kang, Rojesh Shrestra, Michael S Balzer, Shatakshee Chatterjee, Patricia Prado, Seung Yub Han, Hongbo Liu, Xin Sheng, Pieterjan Dierickx, Kirill Batmanov, Juan P Romero, Felipe Prósper, Mingyao Li, Liming Pei, Junhyong Kim, Nuria Montserrat and Katalin Susztak

Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease.

Xin Sheng, Chengxiang Qiu, Hongbo Liu, Caroline Gluck, Jesse Y Hsu, Jiang He, Chi-Yuan Hsu, Daohang Sha, Matthew R Weir, Tamara Isakova, Dominic Raj, Hernan Rincon-Choles, Harold I Feldman, Raymond Townsend, Hongzhe Li and Katalin Susztak

Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease.

Chengxiang Qiu, Shizheng Huang, Jihwan Park, YoSon Park, Yi-An Ko, Matthew J. Seasock, Joshua S. Bryer, Xiang-Xi Xu, Wen-Chao Song, Matthew Palmer, Jon Hill, Paolo Guarnieri, Julie Hawkins, Carine M. Boustany-Kari, Steven S. Pullen, Christopher D. Brown and Katalin Susztak

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease.

Jihwan Park, Rojesh Shrestha, Chengxiang Qiu, Ayano Kondo, Shizheng Huang, Max Werth, Mingyao Li, Jonathan Barasch, and Katalin Suszták