In this study, we performed gene expression (RNA sequencing) analysis on kidney tissue samples obtained from controls and from kidneys of mice with kidney disease. The following models were analyzed:

1. UUO: unilateral ureteral obstruction (7 days after surgery).

2. FAN: folic acid nephropathy (7 days after folic acid injection) (Dhillon et al., 2021; GSE156686).

3. TFAM knock-out; mice with tubule specific deletion of TFAM (mitochondrial transcription factor A) KspCre/Tfamflox/flox (12 weeks) (Chung et al., 2019; GSE134950).

4. APOL1 Tg: podocyte specific G1 and G2 APOL1 transgenic mice NPHS1 rtTA/TRE-APOL1 (Dox food: 4- to 6-week-old male FvB transgenic mice were placed on a doxycycline diet to induce transgene expression) (Beckerman et al., 2017; GSE81492).

5. Col4a3 KO: mice with genetic deletion of Col4a3 (model of Alport syndrome) (Funk et al., 2019).